Combinatorial Chemistry, Part B by Guillermo Morales, Barry A. Bunin

By Guillermo Morales, Barry A. Bunin

Combinatorial Chemistry encompasses either the layout of compounds for particular pharmacological use and the screening of molecules in excessive throughput automatic checks to discover energetic brokers with particular capabilities. *Analytical techniques*Direct sorting break up and pool combinatorial synthesis*Linkers and their applications*Microwave assisted synthesis*Oligosaccharide chemistry*Peptide Synthesis and Screening*Polymer assisted approaches*Small molecule and heterocycle synthesis

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P. Baydal, A. M. Cameron, N. R. Cameron, D. M. Coe, R. Cox, B. G. Davis, L. J. Oates, G. Oye, and P. G. Steel, Tetrahedron Lett. 42, 8531 (2001). u M. E. Attardi, G. Porcu, and M. Taddei, Tetrahedron Lett. 41, 7391 (2000). v T. T. Ngo, Appl. Biochem. Biotechnol. 13, 207 (1986). w An aldehyde (BAL) linker was used as a model for this functional group. x J. Va´zquez and F. Albericio, Tetrahedron Lett. 42, 6691 (2001). y J. J. Cournoyer, T. Kshirsagar, P. P. Fantauzzi, G. M. Figliozzi, T. Makdessian, and B.

S. Rahman, V. de Biasi, and P. Camillero, Anal. Commun. 34, 325 (1997). m T. T. Ngo, Appl. Biochem. Biotechnol. 13, 213 (1986). n O. Kuisle, M. Lolo, E. Quin˜oa´, and R. Riguera, Tetrahedron 55, 14807 (1999). o M. E. Attardi, A. Falchi, and M. Taddei, Tetrahedron Lett. 41, 7395 (2000). p M. E. Attardi, A. Falchi, and M. Taddei, Tetrahedron Lett. 42, 2927 (2001). q B. A. Burkett, R. C. D. Brown, and M. M. Meloni, Tetrahedron Lett. 42, 5773 (2001). n,q s G. L. Ellman, Arch. Biochem. Biophys. 82, 70 (1959).

5 Retention time (min) Fig. 4. d. d. column, at 8 (B), 12 (C), and 16 ml/min (D). 1 mm, were evaluated. The standard mixture was analyzed at flow rates of 6, 8, 10, 12, 14, and 16 ml/min. 5 min. The chromatograms in Fig. d. d. column at 8 ml/min (B), 12 ml/ min (C), and 16 ml/min (D). Below 8 ml/min, the very lipophilic dioctyl phthalate did not elute. The separation was good at 12 ml/min and even better at 16 ml/min. d. column was sufficient to maintain the separation efficiency, and consumed only half the solvent.

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