Containment Systems: A Design Guide by Nigel Hirst, Martyn Ryder, Mike Brocklebank

By Nigel Hirst, Martyn Ryder, Mike Brocklebank

This can be the single booklet that covers containment, in particular for the method industries. This advisor covers the variety of containment apparatus from basic air-flow regulate units to enclosures that limit exposures to good less than a microgram in step with cubic meter averaged over a operating day. the choice of a specific containment process for a selected move operation could be tricky a result of large selection on hand. This consultant offers a based method of the choice approach.

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Toxic, irritant, flammable). It will also give more specific information in the form of: 9 Risk (R) phrases, which are standard phrases giving simple information about the hazards of a chemical in normal use; 9 Safety (S) phrases, which provide advice on the safety precautions that may be appropriate when using the chemical. The basic R-phrases and S-phrases approved for use in the UK are defined in L 100 and listed in Appendix 3 of this guide. Exposure limits As mentioned in Chapter 2, the HSE in the UK publish a new edition every year of EH40, which contains a list of Occupational Exposure Limits (OELs), comprising Maximum Exposure Limits (MELs) and Occupational Exposure Standards (OESs), for use in assessing and ensuring compliance with the COSHH Regulations.

In these predominantly dry process operations there is the potential for release of hazardous materials during transfers between items of equipment and some in-process operations. 2 (page 40) illustrates a generalized process for manufacturing pharmaceuticals in solid dose form, with the transfer operations marked, as before, by asterisk*. 2 suggests, this approach can involve significant handling and transfers. In order to avoid this, the current trend is to couple unit operations closely together, with gravity and/or vacuum transfers of solids between them, and so eliminate open transfers.

1 (b), was to locate the transfer operation in a dedicated room to prevent total contamination of the plant. 1 (c), in which the open transfer operation would take place. Such a booth would be fitted with a local extraction system and would restrict the potential spread of dust or vapour to the adjacent space and so avoid contaminating the rest of the plant. Where manual operations, such as tipping, were required, the operator would carry these out in the booth, wearing PPE as a form of protection against the locally contained contaminant.

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